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| Registros recuperados : 6 | |
| 3. |  | EICHLER, V.; ROLIM, R. B.; MONTEIRO, P. M. F. O.; ASSUNCAO, M. S.; SPEHAR, C. R.; GUIMARAES, L. B. Avaliacao de cultivares e linhagens de soja para o estado de Goias e Distrito Federal: safra 1995/96. In: REUNIAO DE PESQUISA DE SOJA DA REGIAO CENTRAL DO BRASIL, 18., 1996, Uberlandia. Ata e resumos. Uberlandia: UFU; [Londrina]: Embrapa-CNPSo, 1996. p.350-351.| Biblioteca(s): Embrapa Cerrados. |
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| 4. | | EICHLER, V.; ROLIM, R. B.; ASSUNCAO, M. da S.; SPEHAR, C. R.; GUIMARAES, L. B.; BARROS, A. C.; VANDERLEY, J. C.; BARBOSA, F. R.; MOREIRA, W. A. Avaliacao de cultivares e linhagens de soja para o Estado de Goias. In: REUNIAO DE PESQUISA DE SOJA DA REGIAO CENTRAL DO BRASIL, 16., 1994, Dourados. Ata e resumos. Dourados: EMBRAPA-CPAO, 1994. p.136-137. (EMBRAPA-CPAO. Documentos, 3).| Biblioteca(s): Embrapa Soja. |
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| 5. | | EICHLER, V.; ROLIM, R. B.; ASSUNCAO, M. da S.; SPEHAR, C. R.; GUIMARAES, L. B.; BARROS, A. C.; VANDERLEY, J. C.; MOREIRA, W. A. Avaliacao de cultivares e linhagens de soja para o Estado de Goias; safra 1994/95. In: REUNIAO DE PESQUISA DE SOJA DA REGIAO CENTRAL DO BRASIL, 17., 1995, Goiania. Ata e resumos. Goiania: EMGOPA, 1995. p.170. (EMGOPA. Documentos, 28).| Biblioteca(s): Embrapa Soja. |
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| 6. | | FARIA, L. C.; EICHLER V. ROLIM, R. B.; ASSUNCAO, M. S.; MONTEIRO, P. M. F. O.; SPEHAR, C.; GUIMARAES, L. B.; MATOS, F. S.; NEIVA, L. C. S. Descricao da cultivar de soja EMGOPA-316 (Rio Verde). In: CONGRESSO BRASILEIRO DE SOJA, 1999, Londrina. Anais... Londrina: Embrapa Soja, 1999. p.494. (Embrapa Soja. Documentos, 124).| Biblioteca(s): Embrapa Soja. |
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| Registros recuperados : 6 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Cerrados. |
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Data corrente: |
12/12/2018 |
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Data da última atualização: |
12/12/2018 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
STAFUZZA, N. B.; SILVA, R. M. de O.; PERIPOLLI, E.; BEZERRA, L. A. F.; LOBO, R. B.; MAGNABOSCO, C. de U.; DI CROCE, F.; OSTERSTOCK, J.; MUNARI, D. P.; LOURENCO, D. A. L.; BALDI, F. |
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Afiliação: |
Nedenia Bonvino Stafuzza, UNESP; Rafael Medeiros de Oliveira Silva, University of Georgia; ELISA PERIPOLLI, UNESP; Luiz Antônio Framartino Bezerra, USP; Raysildo Barbosa Lôbo, Associaçao Nacional dos Criadores e Pesquisadores; CLAUDIO DE ULHOA MAGNABOSCO, CPAC; Fernando Di Croce, Zoetis; Jason Osterstock, Zoetis; Danísio Prado Munari, UNESP; Daniela A. Lino Lourenco, University of Georgia; Fernando Baldi, UNESP. |
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Título: |
Genome-wide association study provides insights into genes related with horn development in Nelore beef cattle. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
PLoS ONE, v. 13, n. 8, e0202978, August 30, 2018. |
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DOI: |
https://doi.org/10.1371/journal.pone.0202978 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract The causal mutation for polledness in Nelore (Bos taurus indicus) breed seems to have appeared first in Brazil in 1957. The expression of the polled trait is known to be ruled by a few groups of alleles in taurine breeds; however, the genetic basis of this trait in indicine cattle is still unclear. The aim of this study was to identify genomic regions associated with the hornless trait in a commercial Nelore population. A total of 107,294 animals had phenotypes recorded and 2,238 were genotyped/imputed for 777k SNP. The weighted single-step approach for genome-wide association study (WssGWAS) was used to estimate the SNP effects and variances accounted for by 1 Mb sliding SNP windows. A centromeric region of chromosome 1 with 3.11 Mb size (BTA1: 878,631?3,987,104 bp) was found to be associated with hornless in the studied population. A total of 28 protein-coding genes are mapped in this region, including the taurine Polled locus and the IFNAR1, IFNAR2, IFNGR2, KRTAP11-1, MIS18A, OLIG1, OLIG2, and SOD1 genes, which expression can be related to the horn formation as described in literature. The functional enrichment analysis by DAVID tool revealed cytokine-cytokine receptor interaction, JAK-STAT signaling, natural killer cell mediated cytotoxicity, and osteoclast differentiation pathways as significant (P < 0.05). In addition, a runs of homozygosity (ROH) analysis identified a ROH island in polled animals with 2.47 Mb inside the region identified by WssGWAS. Polledness in Nelore cattle is associated with one region in the genome with 3.1 Mb size in chromosome 1. Several genes are harbored in this region, and they may act together in the determination of the polled/horned phenotype. Fine mapping the locus responsible for polled trait in Nelore breed and the identification of the molecular mechanisms regulating the horn growth deserve further investigation. MenosAbstract The causal mutation for polledness in Nelore (Bos taurus indicus) breed seems to have appeared first in Brazil in 1957. The expression of the polled trait is known to be ruled by a few groups of alleles in taurine breeds; however, the genetic basis of this trait in indicine cattle is still unclear. The aim of this study was to identify genomic regions associated with the hornless trait in a commercial Nelore population. A total of 107,294 animals had phenotypes recorded and 2,238 were genotyped/imputed for 777k SNP. The weighted single-step approach for genome-wide association study (WssGWAS) was used to estimate the SNP effects and variances accounted for by 1 Mb sliding SNP windows. A centromeric region of chromosome 1 with 3.11 Mb size (BTA1: 878,631?3,987,104 bp) was found to be associated with hornless in the studied population. A total of 28 protein-coding genes are mapped in this region, including the taurine Polled locus and the IFNAR1, IFNAR2, IFNGR2, KRTAP11-1, MIS18A, OLIG1, OLIG2, and SOD1 genes, which expression can be related to the horn formation as described in literature. The functional enrichment analysis by DAVID tool revealed cytokine-cytokine receptor interaction, JAK-STAT signaling, natural killer cell mediated cytotoxicity, and osteoclast differentiation pathways as significant (P < 0.05). In addition, a runs of homozygosity (ROH) analysis identified a ROH island in polled animals with 2.47 Mb inside the region identified by WssGWAS. Pollednes... Mostrar Tudo |
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Thesagro: |
Bos Indicus; Gado Nelore; Mutação. |
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Categoria do assunto: |
G Melhoramento Genético |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/188280/1/Genome-wide-association-study-provides-apagar.pdf
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Marc: |
LEADER 02768naa a2200289 a 4500
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008 2018 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1371/journal.pone.0202978$2DOI
100 1 $aSTAFUZZA, N. B.
245 $aGenome-wide association study provides insights into genes related with horn development in Nelore beef cattle.$h[electronic resource]
260 $c2018
520 $aAbstract The causal mutation for polledness in Nelore (Bos taurus indicus) breed seems to have appeared first in Brazil in 1957. The expression of the polled trait is known to be ruled by a few groups of alleles in taurine breeds; however, the genetic basis of this trait in indicine cattle is still unclear. The aim of this study was to identify genomic regions associated with the hornless trait in a commercial Nelore population. A total of 107,294 animals had phenotypes recorded and 2,238 were genotyped/imputed for 777k SNP. The weighted single-step approach for genome-wide association study (WssGWAS) was used to estimate the SNP effects and variances accounted for by 1 Mb sliding SNP windows. A centromeric region of chromosome 1 with 3.11 Mb size (BTA1: 878,631?3,987,104 bp) was found to be associated with hornless in the studied population. A total of 28 protein-coding genes are mapped in this region, including the taurine Polled locus and the IFNAR1, IFNAR2, IFNGR2, KRTAP11-1, MIS18A, OLIG1, OLIG2, and SOD1 genes, which expression can be related to the horn formation as described in literature. The functional enrichment analysis by DAVID tool revealed cytokine-cytokine receptor interaction, JAK-STAT signaling, natural killer cell mediated cytotoxicity, and osteoclast differentiation pathways as significant (P < 0.05). In addition, a runs of homozygosity (ROH) analysis identified a ROH island in polled animals with 2.47 Mb inside the region identified by WssGWAS. Polledness in Nelore cattle is associated with one region in the genome with 3.1 Mb size in chromosome 1. Several genes are harbored in this region, and they may act together in the determination of the polled/horned phenotype. Fine mapping the locus responsible for polled trait in Nelore breed and the identification of the molecular mechanisms regulating the horn growth deserve further investigation.
650 $aBos Indicus
650 $aGado Nelore
650 $aMutação
700 1 $aSILVA, R. M. de O.
700 1 $aPERIPOLLI, E.
700 1 $aBEZERRA, L. A. F.
700 1 $aLOBO, R. B.
700 1 $aMAGNABOSCO, C. de U.
700 1 $aDI CROCE, F.
700 1 $aOSTERSTOCK, J.
700 1 $aMUNARI, D. P.
700 1 $aLOURENCO, D. A. L.
700 1 $aBALDI, F.
773 $tPLoS ONE$gv. 13, n. 8, e0202978, August 30, 2018.
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